Bufan M. M. Clinical-pathogenetic features of process of chronic gastritis on a background of duodenogastric reflux and improvement of complex pathogenetic treatment. – Manuscript.
Dissertation for the scientific degree of a candidate of medical sciences by speciality 14.01.36 – gastroenterology. Ivano-Frankivsk State Medical University, Ivano-Frankivsk, 2008.
Dissertation is devoted to the questions of diagnostics and treatment of chronic gastritis on a background of duodenogastric reflux (DGR) taking into account a presence of Helicobacter pylori (H. pylori). During researching there were observed the features of clinical discourse as well as endoscopical and morphological picture of gastric mucosa, gastric acidity, changes of indexes of humoral part of local immune protection and cytokine type of blood in chronic gastritis patients with DGR depending on complication with H. pylori, degree of expressed DGR and inflammatory-atrophy processes in gastric mucosa. There is given a basis for expedience to include altan in complex medical treatment of patients with chronic gastritis on a background of DGR through positive influence on functional activity of stomach, indexes of immunological reactivity, that stimulated regression of clinical-endoscopical expression of disease.
Keywords: chronic gastritis, duodenogastric reflux, Helicobacter pylori, gastric mucosa, immune status, cytokines, altan.
ДГР – дуоденогастральний рефлюкс
ХГ – хронічний гастрит
ВХДПК – виразкова хвороба дванадцятипалої кишки
H. pylori – Helicobacter pylori
СОШ – слизова оболонка шлунка
ЕФГДС – езофагофіброгастродуоденоскопія
Ig – імуноглобуліни
sIg А – секреторний імуноглобулін А
IL – інтерлейкіни
TNF-б –тумор некротизуючий фактор альфа
ЦІК – циркулюючі імунні комплекси