Ключевые слова: микоплазмоз, интерферон, ультраструктура, иммунитет, диагностика.
KHalil Ahmad KHalil Abu Sara. Features of clinical flow, diagnostic, therapy and control of ablation of urogenital mycoplasmosis for women’s. - Manuscript.
The thesis for scientific degree of Candidate of Biological Sciences in speciality 14.01.01. - obstetrics and gynecology. O. O. Bogomolets National Medical University, Health Ministry of Ukraine, Kyiv, 2008.
The thesis deals with perfection of therapy effectiveness urogenital mycoplasmosis with women’s.
The dissertation is devoted the issues of enhancement of efficiency of women’s urogenital mycoplasmosis treatment. It has been determined that clinical course of mycoplasmal infection of women’s urogenital tract doesn’t depend on a type of mycoplasma and it is determined by agent titer in exploratory material, availability of associated mixed infection and the state of organism immunoreactivity system. Sensitivity and peculiar character of immunofluorescence test, culture technique and polymerase chain reaction in diagnostics of mycoplasml infection of urogenital tract correspondingly makes 64,7; 86,6 and 91,6%. Ultrastructural investigation has determined that mycoplasma in endocervix are located in interepithalial, perivascular, intravascular way. Interaction of mycoplasms with host cell takes place in some phases: conglutination, membranes digitation, contacting membranes lysis with further penetration of their content into cell cytoplasm. In immunopathgenesis of mycolasmal infection of urogenital tract the imbalance of immune system has been detected - features of secondary cell immune deficiency and activation oh humoral chain of immunity. It has been determined that clinical flow of urogenital mycoplasmal infection will depend on functioning of immune system, state of immunocompetent cells and their capability to produce various madiators. The necessity and advisability of conducting the comlex therapy for urogenital mycoplasmosis patients has been justified which in addition to etiotropic preparations included the inductor of endogenic interferon “Kagotsel” that resulted in stabilization of immune and interferon status. It has been determined that the most immune molding affect was noticed at use of the treatment regimen including “Polymic” and “Kagotsel” and the rate of recovery of disturbed immune indexes depends on the course of the disease presence of mono - and mixedinfection.
Key words: mycoplasmosis, interferon, ultrastructure, immune resistance, diagnostics.