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Effect of single atropine administration on thecarboxypeptidase h and phenylmethylsulphonilfluoride-inhibited carboxypeptidase activities in rat brain departments and sdrenal
The effect of a single atropine administration on the activities of carboxypeptidase H and phenylmethylsulphonilfluoride-inhibited carboxypeptidase part in the final stage of formation of biologically active neuropeptides from precursors was studied. Changes in the enzymes’ activities after administration were evident during at least 72 h. The results suggest that one of possible mechanisms of reduction of neuropeptide levels by atropine is suppression of activity of enzymes taking part in there metabolism – carboxypeptidase H and phenylmethylsulphonilfluoride-inhibited carboxypeptidase.