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ПРИЛОЖЕНИЕ
Таблица 1. Активность КПН, ФМСФ-ингибируемой КП и АПФ у интактных животных (нмоль продукта, образовавшегося за 1 мин инкубации на 1 мг белка, М ± m, n = 5-6, здесь и в таблицах 2-7: Г - гипофиз, СМ - средний мозг, ГТ – гипоталамус, ГК – гиппокамп, СТ – стриатум, БП – большие полушария, НП – надпочечники, СЕ - семенники)
| Отделы мозга, органы | КПН | ФМСФ – ингибируемая КП | АПФ |
| M±m | M±m | M±m | |
| Г | 1,54±0,01 | 1,36±0,08 | 0,53±0,06 |
| СМ | 0,22±0,02 | 0,31±0,03 | 0,05±0,02 |
| ГТ | 0,24±0,02 | 0,33±0,03 | 0,06±0,01 |
| ГК | 0,28±0,03 | 0,33±0,03 | 0,01±0,001 |
| СТ | 0,18±0,01 | 0,34±0,03 | 0,19±0,03 |
| БП | 0,18±0,01 | 0,35±0,02 | 0,03±0,01 |
| НП | 0,1±0,02 | 1,84±0,1 | 0,01±0,01 |
| СЕ | 0,06±0,01 | 0,3±0,04 | 0,53±0,03 |
Таблица 2. Активность КПН, ФМСФ-ингибируемой КП и АПФ в мозге и тканях крыс при воздействии острого ЭБС (нМ продукта, образовавшегося за 1 мин инкубации на 1 мг белка, М±m, n=5, *- p<0,05, **- p<0,01, ***- p<0,001 к норме, здесь и в таблицах 3-7: I – отдел мозга, орган, II – время после начала воздействия)
| I | II | КПН | ФМСФ-инг. кп | АПФ | |||
| норма | ЭБС | норма | ЭБС | норма | ЭБС | ||
| Г | 0,5 ч.4 ч.24 ч.72 ч.240 ч. | 1,54±0,08 | 2,2±0,23**1,87±0,1*2,02±0,08**2,37±0,12***1,39±0,05 | 1,36±0,07 | 1,18±0,141,26±0,061,46±0,061,67±0,05**1,45±0,07 | 0,53±0,06 | 0,48±0,030,38±0,06**0,53±0,050,58±0,040,46±0,04 |
| СМ | 0,5 ч.4 ч.24 ч.72 ч.240 ч. | 0,22±0,01 | 0,23±0,010,18±0,01*0,22±0,010,22±0,010,21±0,01 | 0,31±0,02 | 0,27±0,020,29±0,010,3±0,020,37±0,01*0,34±0,02 | 0,05±0,02 | 0,05±0,010,02±0,010,02±0,010,04±0,010,02±0,01 |
| ГТ | 0,5 ч.4 ч.24 ч.72 ч.240 ч. | 0,24±0,02 | 0,28±0,020,20±0,010,24±0,010,27±0,030,23±0,02 | 0,33±0,01 | 0,31±0,020,31±0,010,32±0,020,4±0,01**0,34±0,01 | 0,06±0,01 | 0,01±0,010,03±0,0,10,02±0,010,04±0,010,04±0,01 |
| ГК | 0,5 ч.4 ч.24 ч.72 ч.240 ч. | 0,28±0,03 | 0,26±0,010,19±0,01**0,27±0,010,29±0,020,25±0,02 | 0,33±0,02 | 0,29±0,010,32±0,010,35±0,030,42±0,02**0,34±0,01 | 0,01±0,01 | 0,04±0,020,02±0,010,01±0,010,04±0,010,03±0,01 |
| СТ | 0,5 ч.4 ч.24 ч.72 ч.240 ч. | 0,18±0,01 | 0,18±0,020,2±0,010,26±0,01**0,24±0,03*0,18±0,01 | 0,34±0,03 | 0,31±0,030,33±0,020,32±0,010,4±0,020,34±0,01 | 0,19±0,02 | 0,13±0,020,15±0,01**0,15±0,010,18±0,020,19±0,01 |
| БП | 0,5 ч.4 ч.24 ч.72 ч.240 ч. | 0,18±0,02 | 0,21±0,010,18±0,020,19±0,010,24±0,01*0,198±0,01 | 0,35±0,02 | 0,32±0,010,35±0,010,34±0,010,55±0,01***0,37±0,03 | 0,03±0,01 | 0,02±0,010,01±0,000,01±0,000,02±0,010,01±0,00 |
| НП | 0,5ч4ч24ч72ч240ч | 0,1±0,02 | 0,08±0,010,06±,0020,06±0,020,09±0,010,1±,02 | 1,84±0,05 | 1,72±0,091,62±0,05*1,46±0,09**2,88±0,04**1,75±0,02 | 0,01±0,01 | 0,02±0,010,03±0,010,02±0,010,01±0,010,02±0,02 |
| СЕ | 0,5ч4ч24ч72ч240ч | 0,06±0,01 | 0,07±0,010,07±0,020,07±0,020,05±0,010,06±0,01 | 0,3±0,02 | 0,45±0,01*0,3±0,010,31±0,020,27±0,010,25±0,02 | 0,53±0,03 | 0,59±0,01*0,45±0,03*0,47±0,01***0,41±0,010,51±0,02 |
Таблица 3. Активность КПН, ФМСФ-ингибируемой КП и АПФ в мозге и тканях крыс при введении лей-энкефалин-арг (нМ продукта, образовавшегося за 1 мин инкубации на 1 мг белка, М±m, n=5, звездочками показана достоверность: *- p<0,05, **- p<0,01, ***- p<0,001 к норме)